Never trust a scientist. Or an alcoholic.

Foxy: "Whatcha reading there?"
Cali: "Its an essay in PLoS Medicine explaining why most published research findings are false."
Foxy: "Wow. What's it called?"
Cali: "'Why most published research findings are false.'"
Foxy: "And why are they?"
Cali: "Well, the guy reduces it down to a pretty simple relationship between positive predictive value, error rate and bias; PPV = ([1 − β] R+uβR )/( R+ α − β R+u−uα +uβR )"
Foxy: "What?"
Cali: "PPV = ([1 − β] R+uβR )/( R+ α − β R+u−uα +uβR )"
Foxy: "And, umm, what does that mean?"
Cali: "I've got no fucking idea. But, still, are you surprised?"
Foxy: "That more than half of all published science is wrong? Not really. Most scientists use blind faith as a benchmark, arrogance as their guide and follow trends with all the awareness of a fourteen year old girl walking into Abercrombie and Fitch. No, not really surprised."
Cali: "Of course publication, or numbers of publications, are the currency of scientific careers, so its not likely to change. Maybe if those who regularly publish results later proven to be false were to face some kind of consequence?"
Foxy: "Yeah, make em appear on Oprah; 'I feel duped'. Did you see Frey last week? Looked like someone had sprinkled coke on his cornflakes."
Cali: "But she didn't ask the question that really needed answering - if he told a million little lies about his past life and relationships, did he also lie about the road to his recovery? Did he really travel it alone, without the twelve steps and a serenity prayer to his higher power? Inquiring alcoholic minds need to know."
Foxy: "A few persuasive words from the associates of his friend Leonard might be a more effective way to the truth. Another trip to the dentist's chair maybe?"
Cali: "Couldn't be much more painful than Oprah's couch. Who can you trust these days though?"
Tom: "Me! Me! Trust me!"
Foxy: "Oh for fucksake. Did you let him in?"
Cali: "No, he must have been hiding in the closet. So you're here to tell us the Truth, Tom?"
Tom: "You can't handle the truth!"
Foxy: "That wasn't you Tom, that was Jack shouting at you. And, no offence Tom, but you're no Jack."
Tom: "I'm no Jack, I'm Tom! I'm Tom!"
Cali: "Jesus. Can you get him off the couch and back into the closet? I'm off for a drink."
Foxy: "You quit drinking, remember?"
Cali: "Whatever. Maybe I was lying ....."